An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors. Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectorsfurnishes a historical overview of genetic therapyhighlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectorsoffers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trialsdiscusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indicationsillustrates for new practitioners how each stage of genetic therapy is developeddetails genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosisincludes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapyand addresses questions of preparation, delivery, toxicity, mechanism, and specificity. | Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors by Eric Wickstrom, Hardcover | Indigo Chapters