Transforming Growth Factor-jl in Cancer Therapy, Volume I: Basicand Clinical Biology The present volume brings together a wealth of information that is fundamental to understanding the roleofTGF-< in the pathogenesis, prevention, and treatment of cancer. It is not even 25 years sinceTGF-< was first isolated and characterized as a dimeric pep­ tide from both human and bovine sources (1-3), but the entire fieldofTGF-< research has grown and expanded so that it is now a central theme in all of cell biology. There is almost no tissue or organ in the mammalian body in whichTGF-< does not playa central role in embryonic differentiation or in adult function, and furthermore, malfunction of the normal physiologyofTGF- | Transforming Growth Factor-Beta in Cancer Therapy Volume I by Sonia B. Jakowlew, Paperback | Indigo Chapters